Physical Effects of Magic Mushrooms: What to Expect and How to Respond


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Mushrooms contain two active components, Psilocybin and psilocin, for improved mental health and overall well-being. They also treat depression, addiction, and migraines and activate different brain parts. 

We all know that too much of something is poisonous, and so are magic mushrooms. The hallucinogens present in these plants can make you see, feel, or hear things that are not present. You could also experience fear, nausea, anxiety, muscle cramps, or increased blood pressure and heart rate.

When using shroom therapy, you must work with your healthcare giver to recommend and adhere to an appropriate dosage. Below is a guide to help you understand what to expect and how to respond to the physical effects of magic mushrooms: 

What to Expect and How to Respond to Effects of Magic Mushrooms

Immediate Physical Effects

It is usual to experience nausea and gastrointestinal distress after mushroom onset. Nausea could eventually lead to vomiting, while gastrointestinal distress brings stomach discomfort or cramps. What happens is that Psilocybin converts into psilocin, which then reacts with serotonin receptors in the gut, triggering nausea and vomiting.

How long does it take shrooms to kick in depends on the amount of Psilocybin you have consumed. This metabolite activates 5-HT2A receptors in your brain to release hormones and neurotransmitters that influence heart function. Stimulation of such receptors activates the sympathetic nervous system, preparing the flight response to increasing blood pressure and heart rate.

Consumption of magic mushrooms could lead to impairment of coordination and fine motor skills, making it difficult to perform tasks accurately. Psilocybin alters the functionality of the mortar cortex, which helps control, plan, and execute voluntary movements.

The cerebellum is crucial in coordinating movements and maintaining body balance. So, if you wonder how long does it take shrooms to kick in, losing coordination after consumption could be your answer.

Longer-Term Physical Effects

People who use shroom therapy experience mild headaches that could last for hours or a day after Psilocybin has worn off. Encountering a headache answers how long does it take shrooms to kick in. Neurotransmitter levels tend to fluctuate, causing rebound effects in your serotonin system.

Mushroom consumption has a rapid tolerance rate after a short, repeated use. The body develops a tolerance for the psilocybin metabolite, requiring higher amounts to achieve similar effects. However, if you abstain from shroom usage for a week, the tolerance disappears.

Response to How Long Does it Take Shrooms to Kick in

When you experience gastrointestinal distress, take small sips of herbal tea or water to ease your stomach discomfort and stay hydrated. You can also take ginger supplements or ginger tea to prevent the effects of nausea.

Practicing breathing practices, such as slow but deep breaths, is crucial to calm your nervous system. Mindful meditation could also help. These effects are temporary, so stay in a quiet environment to reduce anxiety and physical manifestations. A serene environment helps you know how long does it take shrooms to kick in.


Magic mushrooms are a perfect remedy for improving mental health; however, you are likely to experience physical effects. Common effects include nausea, gastrointestinal distress, increased blood pressure, and impaired coordination. Take sufficient water to stay hydrated and prevent the effects of nausea.

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